Endocrine Abstracts

Introduction: Primary hyperparatyhyroidism (PHPT) is usually caused by single or multiple adenomas and cancer is rare accounting for <1% of all presentations. The presence of certain cytological and architectural features such as adherence to adjacent organs, a solid growth pattern, broad bands of fibrosis, cytological atypia, and an irregular growth contour do not indicate malignancy but are recognised as atypical features encountered more commonly in malignant than benig...

Introduction: Impaired fasting glucose (IFG) is defined as being present in those whose fasting blood glucose level is consistently elevated above normal, but is not high enough to be considered as having diabetes mellitus. Impaired glucose tolerance (IGT) is defined as being present in those whose second hour plasma glucose level is higher than normal, but is not high enough to be considered as having diabetes mellitus. Low serum 25-hydroxyvitamin D levels are associated with...

Objective: Gestational diabetes mellitus (GDM) is strongly associated with maternal obesity. Omentin-1 is secreted from the adipose tissue and enhances insulin action. Circulating levels are inversely correlated with body weight, decreased in type 2 diabetes. Pre-existing maternal obesity has been shown to be associated with lower omentin-1 expression in placenta, adipose tissue and maternal plasma. In our previous study, we had shown that plasma omentin-1 level is decreased i...

Objective: Irisin is a novel adipomyokine that regulates the differentiation and phenotype of adipose tissue. It induces an increase in total body energy expenditure, improves insulin sensitivity, and glucose tolerance. It showed that the levels of irisin are low in obese, diabetic and impaired glucose tolerance patients. However, the information of the levels of circulating irisin in gestational diabetes mellitus (GDM) is controversial. In this study, we investigated i) the l...

Purpose: The purpose of this study was to analyse ghrelin concentrations in the umbilical cord of pregnant women with a diagnosis of gestational diabetes mellitus. The relationship between ghrelin concentrations and birth weights was investigated.Materials and methods: Sixty pregnant women with gestational diabetes mellitus and 64 healthy pregnant women with three oral glucose tolerance test results within normal limits were included in the study. Follow...

Aim: To investigate the relationship between the presence of subclinical target organ damage (STOD) and the levels of ischemia-modified albumin (IMA) in hypertensive patients.Methods: The study included a total of 106 patients, 53 with STOD and 53 without STOD. STOD was deemed present if fundus examination revealed a grade 3–4 retinopathy; the left ventricular mass index (LVMI) was >95 g/m2 in females and >115 g/m2 in m...

Introduction: Accumulating evidence indicate that high PTH resulting from primary or secondary hyperparathyroidism, is associated with hypertension, insulin resistance, dyslipidaemia, obesity, and cardiovascular mortality. Here, we aimed to show whether high PTH levels in obese population contribute the metabolic complications of obesity.Methods/design: The medical records of all subjects attending the obesity outpatient clinic of Kartal Dr Lutfi Kirdar ...

Introduction: Neoplasms of the thyroid gland are classified according to the cell that it originates and commonly they originate from follicular or parafollicular C cells. The most common differentiated thyroid cancers (DTC) are papillary and follicular carcinomas. Coexistence of two different histological types of primary follicular thyroid neoplasm is a rare condition. There are previous reports of concomitant medullary and papillary thyroid cancers. However, there is scarce...

Inflammation has been shown in obese patients in previous studies. Sick euthyroid syndrome is an expected condition in case of inflammatory diseases. In this study, we aimed to investigate the frequency of sick euthyroid syndrome in obese patients without comorbidities and evaluate the association between obesity and inflammation. A total of 390 subjects were enrolled in this case-control study. The study group consisted of 200 obese patients without comorbidities and the cont...

Visfatin/pre-B-cell enhancement factor is an adipocytokine, which is found in the visceral fat tissue and enhances the growth of precursor of B cells through showing synergy with IL7 and stem cell factors. Other cytokines released from the adipose tissue are TNFα and IL6, which has been shown to be related with pathogenesis of insulin resistance, diabetes, dyslipidaemia, inflammation, and atherosclerosis. Our aim was to determine the relationship of plasma visfatin/pre-B-...